This collaboration brings together Kadimastem’s proprietary cell therapy platforms — including AstroRx^® for ALS and IsletRx for diabetes — with TargetGene’s next-generation, DNA-guided gene-editing platform, enabling highly specific, multiplexed genome modifications with minimal off-target activity. The collaboration is expected to continue under the combined company, NewCelX, upon completion of the anticipated merger between NLS and Kadimastem.kdst Pursuant to the MOU, the companies will jointly develop and optimize gene-edited cell therapy products designed to enhance therapeutic performance, stability, and safety. The collaboration aims to accelerate the creation of curative, scalable, and commercially viable cell-based treatments for some of the world’s most challenging diseases. The MOU establishes a framework for joint R&D activities, technology exchange, and future licensing opportunities, forming the basis for a long-term strategic collaboration between the companies. This collaboration represents a key step in Kadimastem’s strategy to expand its pipeline through next-generation gene-edited cell therapies and reinforces its commitment to delivering transformative, disease-modifying solutions to patients worldwide. Prof. Michel Revel, Chief Scientist and Founder of Kadimastem, said:
« The integration of precise gene editing with our stem-cell–derived therapeutic cells potentially opens new horizons in regenerative medicine. This collaboration enables us to tailor cells with enhanced biological properties, improving their survival, function, and therapeutic potential in patients with ALS and other devastating diseases. »   About Kadimastem Kadimastem is a clinical stage cell therapy company, developing « off-the-shelf », allogeneic, proprietary cell products based on its technology platform for the expansion and differentiation of Human Embryonic Stem Cells (hESCs) into functional cells. AstroRx^®, the company’s lead product, is an astrocyte cell therapy in clinical development for the treatment for ALS and in pre-clinical studies for other neurodegenerative indications. IsletRx is the company’s treatment for diabetes. IsletRx is comprised of functional pancreatic islet cells producing and releasing insulin and glucagon, intended to treat and potentially cure patients with insulin-dependent diabetes. Kadimastem was founded by Professor Michel Revel, Chief Scientific Officer of Kadimastem and Professor Emeritus of Molecular Genetics at the Weizmann Institute of Science. Professor Revel received the Israel Prize for the invention and development of Rebif^®, a multiple sclerosis blockbuster drug sold worldwide. Kadimastem is traded on the Tel Aviv Stock Exchange (TASE: KDST).